Synaptophysin

A.Prof Frank Gaillard et al.

Synaptophysin is a membrane glycoprotein found in presynaptic vesicles and is commonly used as an immunohistochemical marker for cells of neuronal (e.g. gangliogliomas) and neuroendocrine lineage (e.g. pheochromocytomas and paragangliomas) 1,2

In the brain, it has been suggested that perisomatic synaptophysin immunohistochemical staining is not seen in normal neurons and therefore is a reliable feature to distinguish neoplastic from non-neoplastic neurons. It appears, however, that this is not always the case; normal brain, as well as non-neoplastic brain tissue, can show synaptophysin staining 3

Share article

Article information

rID: 52217
Section: Pathology
Synonyms or Alternate Spellings:

Support Radiopaedia and see fewer ads

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.