T1 mapping - myocardium

Dr Joachim Feger et al.

T1 mapping is a magnetic resonance imaging technique used to calculate the T1 time of a certain tissue and display them voxel-vice on a parametric map. It has been used for myocardial tissue characterization 1-6 and has been investigated for other tissues 5.

T1 is the spin-lattice or longitudinal relaxation time of tissue and a parametric T1 map depicts those values within its voxels 1-6. T1 reflects changes in intracellular and extracellular compartments and is affected by collagen, protein, water (edema), lipids and iron content 1-5. The histopathological correlate of myocardial T1, however, has still not been completely elucidated 1.

Native T1 is referred to as the T1 time measured in the absence of a contrast agent 1-3, whereas postcontrast T1 measured after the application of gadolinium is used to calculate extracellular volume (ECV), a surrogate parameter for the extracellular matrix  1-4. Both native T1 and ECV can be used as biomarkers 1,2.

Alterations in native T1 are not specific and in the myocardium, they reflect changes in tissue composition.  Together with other imaging or clinical parameters they can help in the diagnosis 1,2.

T1 mapping can be conducted with several different acquisition methods (MOLLI, ShMOLLI, STONE, SASHA, SAPPHIRE) based on balanced SSFP sequences 2,5. Following either an inversion or saturation preparation a series of co-registered images is acquired at different T1 recovery times 2.

T1 values can then be computed pixel-wise from a signal intensity versus time curve fitting model 2,5. Motion between the images needs to be corrected otherwise this will have an adverse effect on the measured T1 values 2,3,5.

The voxels can then be quantified and evaluated either on the basis of normal reference values in diffuse disease or compared to the healthy myocardium in focal disease 2.

If the second set of T1 images after the administration of a gadolinium-based contrast agent is acquired and co-registered to the first native set, an extracellular volume (ECV) map can be generated 1-3.

Native T1 is related to water, protein, lipid and iron content of the respective tissue 1,5. Postcontrast T1 is shorter than native T1 and used to calculate ECV after adjusting for hematocrit 1-5.

Extracellular volume (ECV) reflects the space, which is not occupied by cells and also includes the intracapillary plasma volume 1. It correlates with the collagen volume fraction but also increases in the presence of amyloid or myocardial edema 1.  In the absence of the two latter and other forms of an infiltrative disease, it can be seen as a biomarker for interstitial disease or myocardial fibrosis 1-4.

Myocardial T1 depends on the pulse sequence, cardiac cycle as well as other factors and increases at higher magnetic field strength 6.

T1-mapping can detect a variety of myocardial pathologies, where it shows increased values 2-5:

In addition, it can be used in the following pathologies due to low values 2,5:

The calculation of extracellular volume (ECV) is considered as reasonable in patients getting an extracellular contrast agent and give additional information in some of the above-mentioned pathologies 2-5.

Normal values of T1 times differ depending on magnetic field strength (1.5 and 3 tesla) and acquisition sequence (MOLLI, shMOLLI, SASHA, SAPPHIRE). Because of variations between scanners the primary use of a local reference range is recommended 1,2 and if a local reference range is not available quantitative results should not be clinically reported 1,2.

Article information

rID: 78604
System: Cardiac
Synonyms or Alternate Spellings:
  • Myocardial T1 mapping
  • T1 mapping

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