Thyroid transcription factor 1

Thyroid transcription factor 1 (TTF1) refers to a homeodomain-containing nuclear transcription factor which belonging to the Nkx2 gene family encoded by a gene located on chromosome 14q13.

It is expressed in the forebrain, thyroid and lung tissues. The presence of TTF-1 on a tissue sample is useful in the diagnosis of lung cancer and can be expressed in up to 90% of pulmonary small cell carcinoma but usually not in squamous cell carcinoma.

It is rarely expressed in some primary extrapulmonary tumors 1

Some publications suggest its "overexpression" may result a more favourable overall prognosis 4.

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Article information

rID: 69104
System: Chest
Section: Pathology
Synonyms or Alternate Spellings:
  • Thyroid transcription factor 1 (TTF-1)
  • TTF1
  • TTF 1
  • Thyroid transcription factor 1 (TTF1)

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