Tissue to background ratio

Last revised by Jeremy Jones on 9 Jul 2020

Citation, DOI, disclosures and article data

Citation:

Vajuhudeen Z, Jones J, Murphy A, Tissue to background ratio. Reference article, Radiopaedia.org (Accessed on 18 Apr 2024) https://doi.org/10.53347/rID-79821

DOI:

https://doi.org/10.53347/rID-79821

Permalink:

https://radiopaedia.org/articles/79821

rID:

79821

Article created:

5 Jul 2020, Zemar Vajuhudeen

Disclosures:

At the time the article was created Zemar Vajuhudeen had no recorded disclosures.

View Zemar Vajuhudeen's current disclosures

Last revised:

9 Jul 2020, Jeremy Jones ◉

Disclosures:

At the time the article was last revised Jeremy Jones had no recorded disclosures.

View Jeremy Jones's current disclosures

Revisions:

3 times, by 3 contributors - see full revision history and disclosures

Sections:

Imaging Technology

Synonyms:

Tumour to background ratio, tumor to background ratio

The tissue to background ratio is a measure of the specificity of radiopharmaceutical uptake within the target organ in a nuclear medicine study. It is also referred to as tumor to background ratio in the literature.

The presence of radiopharmaceutical in the background (tissues external to the target organ) can be secondary to the following:

low retention rate in target organ, leading to leakage into surrounding tissues
preferential uptake by other organs (particularly highly vascular structures such as the liver, spleen, gut and kidneys)