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Citation:
Weerakkody Y, Luong D, Fahrenhorst-Jones T, Tumour lysis syndrome. Reference article, Radiopaedia.org (Accessed on 09 May 2024) https://doi.org/10.53347/rID-86645
Tumour lysis syndrome (TLS) is an entity representing a constellation of laboratory and clinical derangements inclusive of:
- hyperuricaemia
- hyperphosphataemia
- hypocalcaemia and
- hyperkalaemia
It is considered an oncological emergency and can occur following treatment of malignancies with high cellular turnover. This results in rapid tumour cell death and is most commonly noted in haematologic malignancies such as acute lymphocytic leukaemia and high-grade non-Hodgkin's lymphoma. It has occasionally been reported with solid organ malignancies.
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1. Zivin SP, Elias Y, Ray CE. Tumor lysis syndrome and primary hepatic malignancy: case presentation and review of the literature. (2015) Seminars in interventional radiology. 32 (1): 3-9. doi:10.1055/s-0034-1396956 - Pubmed
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2. Mirrakhimov AE, Ali AM, Khan M, Barbaryan A. Tumor Lysis Syndrome in Solid Tumors: An up to Date Review of the Literature. (2014) Rare tumors. 6 (2): 5389. doi:10.4081/rt.2014.5389 - Pubmed
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3. Shannon G. Lehner, Jennifer E. Gould, Wael E. A. Saad, Daniel B. Brown. Tumor Lysis Syndrome After Radiofrequency Ablation of Hepatocellular Carcinoma. (2012) American Journal of Roentgenology. doi:10.2214/AJR.04.1265
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4. Calvo Villas J. Tumour Lysis Syndrome. Med Clin (Barc). 2019;152(10):397-404. doi:10.1016/j.medcli.2018.10.029 - Pubmed
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