Twin pregnancy

Twin pregnancies are the most common multifetal pregnancies

Multifetal pregnancies account for ~ 1% of all pregnancies but are seen in much higher numbers in populations where in vitro fertilisation (IVF) is a common practice, most of which are twin pregnancies.

A twin pregnancy can be broadly categorized into 

Also known as fraternal twins resulting from independent fertilization of two ova, and always result in dichorionic - diamniotic pregnancies. This feature alone cannot be used to distinguish dizygotic from monozygotic pregnancies as approximately 20% of monozygotic pregnancies will also be dichorionic-diamniotic (resulting in ~80% of all twin pregnancies being dichorionic-diamniotic). The most reliable sign of dizygosity on ultrasound is documentation of different sex fetuses.

Risk factors for dizygotic pregnancy:

  • in vitro fertilisation (IVF): particularly use of ovulation induction agents
  • advanced maternal age
  • advanced parity
  • maternal family history
  • ethnicity (e.g. Nigerian 1 in 25 in Nigeria to 1 in 155 in Japan) 4 

Also known as identical twins are due to fertilisation of a single ovum that then separates into two. Unlike dizygotic pregnancy, monozygotic pregnancies do not have maternal age, family history or ethnic predisposition. The time at which this separation occurs determines the chorionicity and amnionicity of the pregnancy.

Division at:

All twin pregnancies have a higher fetal and neonatal mortality with overall rates of fetal mortality being 3-6 times that of a singleton pregnancy and neonatal mortality 7 times that of single pregnancies. This is primarily due to a much higher incidence of premature labor and all the sequel thereof. 

The risk of complications and therefore the prognosis is worst for mono-mono and best for di-di:

  • di-di: ~10% perinatal mortality
  • mono-di: ~20% perinatal mortality
  • mono-mono: often >50% perinatal mortality

Monochorionic twin pregnancies share the one placenta and are therefore prone to hemodynamic complications such as:

Amniotic fluid discordance is the most reliable predictor of poorer outcome.

Monoamniotic twin pregnancies share the one amniotic sac and are prone to entangled cords, as well as all the monochorionic complications (since you cannot be dichorionic-monoamniotic).

The role of ultrasound is crucial adequate in the monitoring of the pregnancy and planning for delivery. The number of fetuses and their chorionicity and amnionicity must be determined, as well as monitoring for complications and anomalies. Finding the placental sites of umbilical cord insertion are important because marginal and velamentous insertions increase risk 5.

It is easiest to determine chorionicity and amnionicity in the first trimester.

Dichorionic

  • separate gestational sacs with chorion extending between them ( < 10 weeks)
  • twin-peak sign or (lambda sign) ( > 10 weeks): thick intertwin membrane, with more than two layers
  • separate placental masses (note, however, that most dichorionic pregnancies have placental masses that abut each other
    • however, the thickness is however subjective and becomes progressively more difficult to asses (98% accuracy in the first trimester vs 83% later)
  • twins may be of different genders

Monochorionic diamniotic

  • single gestational sac
  • two yolk sacs 
  • T signthin intertwin membrane
  • single placental mass (note, however, that most dichorionic pregnancies have placental masses that about each other and can be often mistaken for single placenta, especially in the third trimester)

Monoamniotic

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Article information

rID: 1696
System: Obstetrics
Section: Gamuts
Synonyms or Alternate Spellings:
  • Twin pregnancies

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Cases and figures

  • Case 1: DCDA twin pregnancy
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  • Case 2: Twin pregnancy radiograph
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