Van der Woude syndrome

Last revised by David Luong on 24 Jun 2021

Van der Woude syndrome (VWS) is characterized by the association of congenital lower lip fistulae/pits with cleft lip and/or palate.

It is one of the most common clefting syndromes in humans 1 and affected individuals have a high prevalence of hypodontia.

Pathology

Genetics

It carries an autosomal dominant inheritance. Although caused by a single gene mutation, Van der Woude syndrome has variable phenotypic expression.

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