Williams-Campbell syndrome

Williams-Campbell syndrome (WCS) is a rare form of congenital cystic bronchiectasis, in which distal bronchial cartilage is defective.

Williams-Campbell syndrome may present with recurrent pneumonia, wheezing, barrel-chest deformity, and Harrison sulcus 8.

It is thought to result from a deficiency of cartilage formation in the 4th to 6th order sub-segmental bronchi, resulting in distal airways collapse 7.

Cystic central bronchiectasis changes, usually symmetric and bilateral, typically involving 4th to 6th order bronchi with preservation of the trachea and main bronchi 2

All causes of diffuse and bilateral bronchiectasis including:

The syndrome was first described by Howard Williams and Peter Campbell in 1960 8.

Chest

Article information

rID: 9743
Synonyms or Alternate Spellings:
  • Williams-Campbell syndrome
  • Williams-Campbell syndrome (WCS)

ADVERTISEMENT: Supporters see fewer/no ads

Cases and figures

  • Case 1
    Drag here to reorder.
  • Case 2
    Drag here to reorder.
  • Case 3
    Drag here to reorder.
  • Updating… Please wait.

     Unable to process the form. Check for errors and try again.

     Thank you for updating your details.