There is a significant correlation between T1 and T2 relaxation rates and the liver iron content yielded by biopsy ¹. Due to the absence of radiofrequency refocusing, gradient echo sequences are the most sensitive in detecting small amounts of iron ². The signal changes here appear to be the opposite of those in hepatic steatosis. However, this phenomenon is not based on chemical shift, but on susceptibility effects, for the in-phase echo is the second echo of the double gradient-echo sequence, and is therefore acquired at a longer TE. This allows more time for dephasing due to field inhomogeneities.