There is diffusion restriction involving the left frontal cortex, predominantly anteriorly and in a parafalcine position. There is some mild parafalcine left parietal cortical diffusion restriction. Further diffusion restriction of the left caudate head is present, and there is faint diffusion restriction involving the left putamen and the head of right caudate and putamen. No convincing white matter involvement. There is mild corresponding high FLAIR and T2 signal intensity in these regions.
No other intra or extraaxial abnormality. No mass-effect. Ventricles and sulci are within normal limits for age. No posterior fossa abnormality. No suspicious enhancing lesions, in particular, no parenchymal or leptomeningeal enhancement.
Diffuse myelomatous deposits involving the calvarium again noted. Right maxillary paranasal sinus mucosal disease noted.
Diffusion restriction involving the left frontoparietal cortex (frontal > parietal) and left caudate head. The pattern of diffusion restriction and abnormality is suspicious for Creutzfeldt-Jakob disease. Vasculitis and ischaemia/infarction in the left anterior circulation territory are less likely differentials.