There is diffusion restriction involving the left frontal cortex, predominantly anteriorly and in a parafalcine position. There is some mild parafalcine left parietal cortical diffusion restriction. Further diffusion restriction of the left caudate head is present, and there is faint diffusion restriction involving the left putamen and the right head of caudate and putamen. No convincing white matter involvement. There is mild corresponding high FLAIR and T2 signal intensity in these regions.
No other intra or extraaxial abnormality. No mass-effect. Ventricles and sulci are within normal limits for age. No posterior fossa abnormality.
No suspicious enhancing lesions, in particular no parenchymal or leptomeningeal enhancement.
Diffuse myelomatous deposits involving the calvarium again noted.
1. Diffusion restriction involving the left frontoparietal cortex and left caudate head. The pattern of diffusion restriction and abnormality is suspicious for Creutzfeldt-Jakob disease.
2. No evidence of intracranial myelomatous involvement.
3. Calvarial myelomatous involvement.