Typical presentation, imaging and EEG findings of Creutzfeldt-Jacob disease (CJD).
Cerebrospinal fluid (CSF)
- CJD Protein (14-3-3): POSITIVE
- Protein 0.47H g/L (normal <0.45)
- Glucose 4.1H mmol/L (normal 2.2-3.9)
COMMENT: The 14-3-3 protein is a non-specific marker of central nervous system neuronal injury or death. A positive result has approximately 90% sensitivity and specificity for sporadic Creutzfeldt-Jacob disease. "False" positives are frequently recognized in encephalitis (especially Herpes simplex) & recent cerebral infarcts.