The degree of atrophy in advanced dementia can be striking. The preferential involvement of the hippocampi and parahippocampal gyri, with relative sparing of the rest of the temporal lobe is fairly typical of Alzheimer disease or limbic-predominant age-related TDP-43 encephalopathy (LATE). 

Unfortunately, these two entities can not only mimic each other clinically and radiologically but can also co-exist. An amyloid PET can be useful but currently, a definite antemortem diagnosis cannot be reached.