Adamantinomatous craniopharyngioma

Discussion:

The patient underwent an endoscopic transsphenoidal debulking of the recurrent craniopharyngioma, followed by postoperative radiotherapy.

Histology

Paraffin sections show small fragments of craniopharyngioma. These consist of epithelial islands within a loose fibrous stroma. The epithelial islands show a peripheral basaloid layer, central squamous epithelium and a stellate reticulum layer.  Several cystic spaces filled with loose amorphous eosinophilic material are noted and there are several foci of dystrophic calcification.  No mitotic figures or areas of necrosis are identified.

Final diagnosis

Adamantinomatous craniopharyngioma.

 

This case illustrates the typical pathological and radiological features of adamantinomatous craniopharyngioma. 

 

Case courtesy of Dr. Frank Gaillard

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