Phthisis bulbi, also known as end-stage eye, is an atrophic scarred and disorganized globe that may result from a variety of severe ocular insults. Dystrophic calcification is common.

Causes of this end-stage damage include trauma, infection, other inflammatory processes, radiation, chronic retinal detachment, persistent hyperplastic primary vitreous and retinoblastoma. The globe is non-functioning thus the patient is blind in that eye. Enucleation +/- prosthesis insertion is performed if there is associated with chronic pain or for cosmetic reasons.

Credit: Dr Donna D'Souza