Epithelioid sarcoma pulmonary metastases

Case contributed by Maxim Stalkov
Diagnosis certain

Presentation

Chest pain, cough and hemoptysis. Resection of finger lesion a few years ago histologically identified as "inflammatory pseudotumor".

Patient Data

Age: 30 years
Gender: Female

Multiple cystic lesions accompanied by ill-defined nodules and a dominant solid mass in the right upper lobe. Peri-lesional ground-glass changes are demonstrated. Small left-sided pneumothorax.

Findings are consistent with cystic and solid hemorrhagic pulmonary metastases, complicated by pneumothorax.

Biopsy revealed epithelioid sarcoma metastases.

Case Discussion

Epithelioid sarcoma is a rare soft tissue tumor with unclear histogenesis that represents the most common soft tissue sarcoma of a hand. This tumor is often mistaken for a chronic inflammatory process or necrotizing granuloma due to its innocuous presentation as well as unusual both epithelial and mesenchymal differentiation (immunohistochemistry stains were positive for vimentin and cytokeratin 8). Epithelioid sarcoma has known propensity for pulmonary metastases, which can present as cystic lesions and be complicated by the development of pneumothorax and hemorrhage. 

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