Pituitary macroadenomas are the most common suprasellar mass in adults, and responsible for the majority of transsphenoidal hypophysectomy.

On imaging they usually present as a solid tumor with an attenuation similar to brain (30-40 HU) and demonstrates moderate contrast enhancement. The same is observed on MRI, where they are isointense to the grey matter both on T1 and T2-weighted images. However attenuation and signal characteristics can significantly vary depending on tumor components such as hemorrhage, cystic transformation or necrosis.