Pulmonary tuberculosis with COPD

Discussion:

In both the conditions, pulmonary TB and COPD there is destruction of pulmonary extracellular matrix. The micobacterium cell wall antigen lioparabinomannan (LAM) is responsible for matrix metalloproteinases (protease) and immune mediated breakdown of extracellular matrix collagen. Smoking also enhances protease and elastase activity in the extracellular matrix thus result in destruction of collagen. In long standing tubercular infections COPD may be a complication1.

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