Tuberous sclerosis

Discussion:

The clinical triad of tuberous sclerosis in a young female includes seizures, learning difficulties, and adenoma sebaceum. The neurological findings most commonly include cortical tubers and subependymal nodules. Abdominal findings include renal angiomyolipomas, some of which may have vessel dilatation (macroaneurysm) and have the propensity to bleed when large enough. Hepatic angiomyolipomas are also seen in patients with tuberous sclerosis. Association of tuberous sclerosis with pulmonary lymphangioleiomyomatosis (LAM) has been documented.

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