Radiology Quiz 5127 | Radiopaedia.org

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How does primary CNS lymphoma differ from systemic lymphoma with CNS involvement?

By definition there is no co-existing systemic disease at the time of diagnosis, distinguishing it from CNS involvement from systemic lymphoma (secondary CNS lymphoma).

Question 2

What type of lymphoma is most commonly found in patients with primary CNS lymphoma?

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The vast majority (>90%) of PCNSL are B cell in origin: diffuse large B-cell lymphoma and high-grade Burkitt-like B-cell lymphoma

Question 3

What predisposing factors are recognised?

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Predisposing factors include: HIV/AIDS, prior EBV infection, post transplantation, IgA deficiency, and Wiskott-Aldrich syndrome.

This patient went on to have a stereotactically guided biopsy (as the diagnosis of lymphoma was strongly suspected on imaging), and this confirmed the diagnosis: high grade B-cell lymphoma.