MICROSCOPIC DESCRIPTION: The sections show scattered chronic inflammatory cells in the parenchyma and in a perivascular distribution. They are mainly lymphocytes with some histiocytes. No neutrophils or eosinophils. There is one toxoplasma cyst containing bradyzoites (H&E stain). No tachyzoites. No granulomas or viral inclusions. The lymphoid cells show reactive changes. No evidence of malignancy.
Gram, Grocott and Ziehl-Neelsen stains (not shown) did not show the presence of bacteria, fungi or acid fast bacilli, respectively.
CMV and HSV1-2 immunostains (not shown) were negative. Most of the lymphocytes are CD3+ T-cells. No evidence of lymphoma/leukaemia.
Diagnosis: Cerebral toxoplasmosis.