Huntington disease

Discussion:

Huntington Disease (HD) is a triple-repeat, CAG, expansion genetic disorder with motor, cognitive and behavioral manifestation. These symptoms are commonly attributed to the characteristic MRI findings of caudate, putamen and frontal-predominant cortical atrophy.  On MRI, the symptoms of apathy and executive deficits (e.g. on symbol digit modality test) seem to correlate with atrophy of basal ganglia in HD1. Measurement of caudal atrophy can be readily compared to the width of the inner-table skull or the lateral ventricular frontal horn measurement.

Several functional imaging/nuclear tracers have been used to study the basal ganglia to predict the onset of HD manifestation. These tracers include Tc 99m–ethyl cysteinate dimer, 18F-FDG PET and 11C-Raclopride2,3. These tracers may suggest reduced activity of the caudate and putamen. However, the clinical utility of these tracers, especially in the pre-manifest or early HD, is yet to be determined. Therefore, although the functional imaging in this case supports the diagnosis of HD, it is not a sole diagnostic investigation. 

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