Secondary bone lymphoma

Discussion:

The patient is diagnosed with Non-Hodgkin-Lymphoma (NHL) with secondary bone involvement confirmed by bone marrow aspirate and biopsy.

Secondary bone lymphoma is lymphoma involving the bone with nodal disease occurring within six months or secondary lymphoma involving the bone at least six months after diagnosis. Secondary bone involvement can result from direct spread from nodal disease or hematogenous metastases. The axial skeleton is more often affected than the appendicular skeleton with the most frequent location is the spine.

Osseous involvement varies from lytic lesions, permeative bone destruction with cortical breach ± adjacent soft tissue mass.

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