Pilocytic astrocytoma
The patient went on to have a resection.
Histology
Sections show a variably cellular tumor with a prominent microcystic architecture. Tumor cells
demonstrate elongated oval nuclei with inconspicuous nucleoli set within a fibrillary stroma. Frequent Rosenthal fibers and eosinophilic granular bodies are seen. There are focal aggregates of thin-walled, hyalinised blood vessels with the adjacent parenchyma containing hemosiderin deposition. No mitoses, necrosis or microvascular proliferation are identified.
IMMUNOHISTOCHEMISTRY RESULTS:
- GFAP: Positive
- IDH-l R132H: Negative (non-mutated)
- ATRX: Positive (non-mutated)
- p53: Positive
- BRAF V60oE: Negative
- Topoisomerase labeling index: Approximately 1-2%.
FINAL DIAGNOSIS: Pilocytic astrocytoma (WHO Grade I).
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