Imaging findings of tracheal wall thickening may be considered according to pattern of focal vs diffuse involvement of the upper airway (see article for more). The presenting symptom of hemoptysis is nonspecific, as it may occur with infectious/inflammatory etiologies or neoplasia. In this case, the circumferential irregular tracheal thickening on CT has a mass-like appearance (particularly at the carina), most consistent with tumor. As the lesion is centered in the trachea and there is no other known malignancy, the main diagnostic consideration is primary tracheal tumor.

Although primary tumors of trachea are rare, they most commonly arise from epithelial cells (squamous cell carcinoma) or salivary glands (adenoid cystic, mucoepidermoid carcinomas). Adenoid cystic carcinomas were previously known as "cylindromas" due to their circumferential growth pattern and resulting cylindrical appearance by imaging.

Histopathology

Trachea, "endobronchial lesion," biopsy

The tumor predominantly shows a cribriform pattern, consistent with a Grade 2 adenoid cystic carcinoma in this biopsy material, which may not be representative of the entire tumor.

Diagnosis: Adenoid cystic carcinoma