Macroscopy: A tan biopsy 3mm, with accompanying blood clot up to 14mm in aggregate. 

Microscopy: The sample mostly comprises blood, pancreatic acini and ductal epithelium. There are a few loosely cohesive aggregates (up to 1mm) of cells with small and round nuclei, fine chromatin, inconspicuous nucleoli and moderate amounts of granular and eosinophilic cytoplasm. Mitoses are not seen. With immunohistochemistry, these cells show positive staining for cytokeratin AE 1/3, synaptophysin and chromogranin. The Ki-67 index is less than 2%. 

Conclusion: Pancreatic body biopsy: limited sample compatible with a low-grade neuroendocrine tumour. 

Loading...