Marchiafava-Bignami disease

Case contributed by Bálint Botz
Diagnosis certain

Presentation

Known chronic alcohol abuse. Disorientated and somnolent.

Patient Data

Age: 50 years
Gender: Male
ct

The entire corpus callosum is homogeneously hypodense. 

Case Discussion

With the history in mind the imaging appearance is pathognomonic for advanced Marchiafava-Bignami disease. Despite the prompt diagnosis and management in ICU the comatose state of the patient gradually worsened over the next few days and he eventually succumbed to the disease. 

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