Langerhans cell histiocytosis. Hand Schueller Christian: Chronic disseminated form, multifocal.
20 year old boy with diabetes insipidus, cough, fever, shortness of breath.
Conventional CT reveals multiple small nodules thin-walled, irregular cysts predominantly in the upper 1/3 of the lungs.
Lytic defect of the parietal, frontal and maxillary bones in the skull.
Other lytic lesions in the femur (no image)
Etiology: Uncertain; Inflammatory ~ neoplastic
Epidemiology: Affects 4 per 1 million
Gender: M:F = 2:1