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Adrenoleukodystrophy

Case contributed by Frank Gaillard
Diagnosis almost certain

Patient Data

Age: 15 years
Gender: Male

MRI brain

mri

MRI of the brain demonstrates increased T2 signal and reduced T1 signal in the white matte of the cerebral hemispheres posteriorly. There is faint enhancement at the anterior margin of the signal abnormality.

Subcortical u-fiber sparing

Annotated image

Note how the subcortical u-fibers are spared until later in the disease. 

Case Discussion

This case illustrates typical features of adrenoleukodystrophy. 

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