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Oligodendroglioma NOS (grade 3)

Case contributed by Frank Gaillard
Diagnosis certain

Patient Data

Age: Adult

Note: This case has been tagged as "legacy" as it no longer meets image preparation and/or other case publication guidelines.

Note: The diagnostic criteria reflect practice at the time of publication and do not necessarily match the current WHO classification of CNS tumors

Right high frontal intra axial lesion with marginal enhancement

Case Discussion

The patient went on to have a resection. 

Histology

Microscopic Description:

Sections show brain tissue infiltrated by a glial tumor that displays oligodendroglial features. Tumor infiltration into adjacent brain tissue is represented by subpial infiltration, focally prominent neuronal satellitosis and linear profiles of tumor cells. Perivascular infiltration by tumor cells is also observed. In the more cellular areas, the tumor cells display characteristic oligodendroglial features. Mitotic activity is increased in areas. Very focal vascular neogenesis is noted, represented by focal proliferation of endothelial cells. Tumor necrosis is not seen.

Final Diagnosis: anaplastic oligodendroglioma

Note: This case predates the 2016 revision WHO classification of CNS tumors, and thus molecular markers (IDH mutation and 1p19q co-deletion) are not available. As such, this tumor would now be classified as an oligodendroglioma NOS grade 3.

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