Brainstem ganglioglioma

Case contributed by Dr Hani Salam

Presentation

Dizziness, vertigo, and nystagmus

Patient Data

Age: 6 years
Gender: Male
MRI

Ganglioglioma centered on the left middle cerebellar peduncle.

Case Discussion

Pathologically-proven ganglioglioma

Pathology report:

  • Immunohistochemistry

GFAP+, Ki-67 very focally increased, NEU-N-, NFP, P53+, SYNAPT+

  • Diagnosis:

brainstem tumor:
cerebellar tissue, no neoplasm seen
ganglioglioma

Comment
Although most ganglioglioma are of WHO grade I, with no definitive established criteria for grade II ganglioglioma, this tumor shows diffuse pattern, as demonstrated on NFP immunostain and very focal increase in Ki-67 proliferation index. The overall features probably favor more grade II ganglioglioma.

PlayAdd to Share

Case information

rID: 10763
Published: 18th Sep 2010
Last edited: 13th Aug 2019
Inclusion in quiz mode: Included

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.