Brainstem ganglioglioma

Case contributed by Dr Hani Salam

Presentation

Dizziness, vertigo, and nystagmus

Patient Data

Age: 6 years
Gender: Male
MRI

Ganglioglioma centered on the left middle cerebellar peduncle.

Case Discussion

Pathologically-proven ganglioglioma

Pathology report:

Immunohistochemistry

  • GFAP+, Ki-67 very focally increased, NEU-N-, NFP, P53+, SYNAPT+

Diagnosis:

brainstem tumor:
cerebellar tissue, no neoplasm seen
ganglioglioma

Comment
Although most gangliogliomas are of WHO grade I, with no definitive established criteria for grade II ganglioglioma, this tumor shows a diffuse pattern, as demonstrated on NFP immunostain and very focal increase in Ki-67 proliferation index. The overall features probably favor more grade II ganglioglioma.

PlayAdd to Share

Case information

rID: 10763
Published: 18th Sep 2010
Last edited: 17th Oct 2019
Inclusion in quiz mode: Included

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.