Case contributed by A.Prof Frank Gaillard

Case Discussion

Final Diagnosis: 

Right frontal lesion: gangliocytoma.


Sections show multiple small fragments of neuropil containing focal collections of atypical ganglion cell neurons. These cells have large round nuclei with prominent nucleoli, abundant cytoplasm and peripheral Nissl substance. The cells are atypical in their morphology, orientation and spacial arrangement. Many blood vessels are surrounded by small cuffs of reactive lymphocytes. The intervening neuropil shows a mild degree of reactive gliosis, occasional axonal steroids and multiple small calcified deposits, resembling psammoma bodies. There does not appear to be any neoplastic glial component to this lesion.

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Case information

rID: 4299
Published: 6th Aug 2008
Last edited: 13th Aug 2019
Inclusion in quiz mode: Included

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