Case contributed by Dr Roberto Schubert


Recurrent upper right quadrant pain, slightly elevated liver enzymes, little acoustic shadowing of the liver on US

Patient Data

Age: 50 years
Gender: Female

Marked signal loss of the liver parenchyma on in-phase T1-weighted GRE and T2 FSE images (use the spleen for comparison).

Case Discussion

There is a significant correlation between T1 and T2 relaxation rates and the liver iron content yielded by biopsy 1. Due to the absence of radiofrequency refocusing, gradient echo sequences are the most sensitive in detecting small amounts of iron 2. The signal changes here appear to be the opposite of those in hepatic steatosis. However, this phenomenon is not based on chemical shift, but on susceptibility effects, for the in-phase echo is the second echo of the double gradient-echo sequence, and is therefore acquired at a longer TE. This allows more time for dephasing due to field inhomogeneities. 

PlayAdd to Share

Case information

rID: 14716
Published: 24th Aug 2011
Last edited: 13th Aug 2019
Inclusion in quiz mode: Included

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.