Heterotopic ossification (post amputation)

Case contributed by Dr Matt A. Morgan


The patient suffered a spinal cord injury as well as traumatic injuries to the lower extremity. The lower extremity injuries were complicated by ischemia and gangrene and amputation was performed. The patient presents as an outpatient for routine check up.

Patient Data

Age: 25Y
Gender: Male

Soft tissue calcification around the femoral diaphysis amptuation margin. The trabecular pattern of the heterotopic calcification indicates that it is heterotopic ossification.

Case Discussion

Heterotopic ossification (HO) around amputations is a problem for doctors as long as soldiers have received amputations for battle injuries.

The pathophysiology of heterotopic ossification is not completely understood, but it is thought that it gets its start when osteogenic precursor cells are activated in the soft tissues due to changes in the local tissue environment.

The prevalence of heterotopic ossification after lower limb amputation has been estimated to be between 23-64%.

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Case information

rID: 37890
Published: 25th Jun 2015
Last edited: 14th Aug 2019
Inclusion in quiz mode: Included

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