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L-asparaginase induced pancreatitis in childhood acute lymphoblastic leukemia

Case contributed by Sajoscha A. Sorrentino
Diagnosis almost certain

Presentation

Background of childhood acute lymphoblastic leukemia, with elevated amylase and lipase.

Patient Data

Age: 10 years
Gender: Male

Enlarged pancreas and peripancreatic fluid in the lesser sac and left pararenal space. 

Case Discussion

L-asparaginase has been part of the treatment of childhood onset ALL for many decades now. L-asparaginase induced pancreatitis is known to be a major complication of this treatment, but the pathophysiology behind this is still to be found. 

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