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Leukoencephalopathy with calcifications and cysts (histology)

Case contributed by Frank Gaillard
Diagnosis not applicable

Histology of a patient with leukoencephalopathy with calcifications and cysts demonstrating a combination of calcification and gliosis with exuberant Rosenthal fiber formation. The calcification can be linear alongside blood vessels (upper left panel) and therefore can mimic Fahr’s disease. 

Histology courtesy of Professor Michael Gonzales, Royal Melbourne Hospital, Australia. 

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