Pineocytoma with astrocytic differentiation

Case contributed by A.Prof Frank Gaillard


Increasing headaches

Patient Data

Age: Adult

A large enhancing mass is present in the pineal region compressing the tectum and resulting in obstructive hydrocephalus. 

The patient went on to have surgery and resection of the mass. 


Sections show a tumour comprised of cells with small rounded nuclei with a moderate degree of pleomorphism. Some hyperchromatic nuclei are present, some of these with eosinophilic cytoplasmic inclusions. Cells show minimal cytoplasm but show elongated cell processes. In many areas the tumour shows anuclear zones. Mitoses are rare (there is only one seen in all of the sections). There is no endothelial proliferation and there is no necrosis. Immunohistochemistry shows that the tumour is strongly positive for synaptophysin and focally positive for neuron-specific enolase. Many of the tumour cells are positive for glial fibrillary acidic protein (GFAP).

Case Discussion

Path proven pineocytoma.

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Case information

rID: 4068
Published: 16th Jul 2008
Last edited: 13th Aug 2019
Inclusion in quiz mode: Included

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