A 30-year-old woman came through the Emergency Department with symptoms of pneumonia. A chest x-ray revealed an incidental 2cm nodule within the right lung. An excisional biopsy was performed.
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The section shows alveolated lung parenchyma with a solitary, well-circumscribed, nodule showing a lobulated architecture and composed of cytologically bland mature chondroid and adipose tissue. There is no evidence of atypia or malignancy and the lesion was clear of the pathological margin.
This was a classic incidental presentation of a benign, hamartomatous lesion, with a characteristic lobulated architecture and composed of a haphazard admixture of chondroid and adipose elements showing no features of atypia or malignancy.
Pulmonary hamartoma should be distinguished from Pulmonary chondroma, which is associated with Carney Triad and are composed only of cartilage and bone with a peripheral fibrous pseudocapsule and lack adipose, smooth muscle and entrapped pulmonary elements, which may be seen in pulmonary hamartomas.
- Rodriguez FJ1, Aubry MC, Tazelaar HD, Slezak J, Carney JA. Pulmonary chondroma: a tumor associated with Carney triad and different from pulmonary hamartoma. Am J Surg Pathol. 2007 Dec;31(12):1844-53 Pubmed citation