Presentation
Whole-brain prophylactic radiation therapy 5 years prior. Presents with gradual-onset impaired cognition.
Patient Data
Mild non-specific predominantly patchy white matter hyperintensities.
5 years later, marked confluent subcortical T2/FLAIR hyperintensities have appeared. Note also hyperintensities surrounding the dentate nuclei. Cerebral and cerebellar atrophy has also significantly progressed. There are no significant microhemorrhages on gradient echo sequences. Note the typical sparing of U-fibers in radiation-induced leukoencephalopathy.
Case Discussion
Typical appearance with U-fiber sparing of radiation leukoencephalopathy.