Rathke's cleft cyst - claw sign

Case contributed by Amro Omar
Diagnosis almost certain

Presentation

Panhypopituitarism.

Patient Data

Age: 45 years
Gender: Male

Non enhancing cystic sellar mass with hypointense non-enhancing hypointense intracystic nodule and claw sign in post-contrast study.

Incidental finding of chronic sphenoid sinusitis.

Note the "Claw" sign = enhancing rim of compressed pituitary surrounding non-enhancing cyst.

Case Discussion

"Claw" sign = enhancing rim of compressed pituitary surrounding non-enhancing cyst.

Rathke cleft cyst is a nonneoplastic cyst arising from remnants of embryonic Rathke cleft.

Top differential diagnoses:

  • craniopharyngioma

  • cystic pituitary adenoma

  • other non-neoplastic cysts

The claw sign has also been used in radiological literature with respect to Wilms tumor.

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