Hemorrhagic glioblastoma

Discussion:

The patient underwent stereotactic craniotomy and excision of the right occipital lesion. 

Histology

MICROSCOPIC DESCRIPTION: Sections of brain show a moderately cellular glioma consisting of crowded, elongate hyperchromatic nuclei in a fibrillary background, with occasional gemistocytic cells. There are small vessels in the background. Some necrosis may be secondary to hemorrhage, however there are thrombosed vessels and associated necrosis which is most consistent with tumor necrosis. There is focal microvascular proliferation. Ki67 30%

  • Positive
    • GFAP
  • Negative
    • IDH-1 R132H
    • p16 CDKN2A

FINAL DIAGNOSIS: Glioblastoma (WHO grade IV).

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