Histology
Five rubbery pale tan/red fragments up to 6mm in greatest dimension.
MICROSCOPIC DESCRIPTION: The vascular fibrofatty and muscular tissue shows a few small foci of poorly cohesive malignant cells some of which show a signet ring cell appearance.
- Immunostaining for her2 oncogene product is negative.
- Ecadherin staining shows weak focal staining interpreted as non specific and negative.
- Oestrogen receptor: postive
- Percentage of nuclei stained: >95
- Predominant intensity of staining: strong
- Progesterone receptor: postive
- Percentage of nuclei stained: >95
- Predominant intensity of staining: strong
FINAL DIAGNOSIS: Left clavicular biopsy: Metastatic carcinoma consistent with a primary lobular breast cancer.