Histology

Five rubbery pale tan/red fragments up to 6mm in greatest dimension.  

MICROSCOPIC DESCRIPTION: The vascular fibrofatty and muscular tissue shows a few small foci of poorly cohesive malignant cells some of which show a signet ring cell appearance.

  • Immunostaining for her2 oncogene product is negative.
  • Ecadherin staining shows weak focal staining interpreted as non specific and negative.
  • Oestrogen  receptor: postive
    • Percentage of nuclei stained: >95
    • Predominant intensity of staining: strong
  • Progesterone  receptor: postive
    • Percentage of nuclei stained: >95
    • Predominant intensity of staining: strong

FINAL DIAGNOSIS: Left clavicular biopsy:  Metastatic carcinoma consistent with a primary lobular breast cancer.

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