Marchiafava Bignami disease

Discussion:

Malnutrition / malabsorption in chronic alcoholics and secondary vitamin B deficiency can result in a spectrum of neurologic disorders as thiamine is an important component of multiple basic functions - co factor in cellular respiration, ATP production, glutamate synthesis and myelin sheath maintenance. The symmetric involvement of both cerebral hemispheres weighs heavily in favor of Wernicke encephalopathy rather than any other form of demyelination. The symmetric involvement of splenium of corpus callosum favors Marchiafava Bignami disease.

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