GD: Neuro - White matter disease
The radiological findings are typical for Megalencephalic leukoencephalopathy with subcortical cyst (MLC) or Van der Knaap syndrome
MLC is a neurodegenerative leukoencephalopathy with genetic mutation affecting astrocyte dysfunction. It is a rare spongiform leukoencephalopathy with diffuse white matter swelling.
The hallmark of radiological diagnosis is: