Hypoxic-ischemic brain injury in a full term infant


Severe asphyxia in term neonates result in injury involving the deep gray matter (putamina, ventrolateral thalami, hippocampi, dorsal brainstem, and lateral geniculate nuclei) and occasionally the perirolandic cortex.

These areas of the brain are actively myelinating (an energy-intensive process) or contain the highest concentrations of NMDA receptors at term and are, therefore, the most susceptible to neonatal hypoxic ischemic insult.