Pathohistology

MACROSCOPIC DESCRIPTION
1.  Specimen  container  labelled  'left  tracheal  biopsy'.  A  tan tissue fragment, 3 mm.  

2.  Specimen  container  labelled '(R)  main bronchus  tumour'.  Three tan tissue fragments, admixed with blood  clot, ranging in  size from 5-10 mm. 

MICROSCOPIC DESCRIPTION
1.  Sections show  a single fragment  of bronchial tissue. This comprises respiratory type  epithelium  with attached  fibrous stroma  infiltrated by nests of  epithelioid  cells.  These  cells  have rounded  nuclei,  finely divided  chromatin, and  moderately  abundant  amphophilic  cytoplasm.  The appearances  are  in  keeping a  carcinoid  tumour.  There  is no  mitotic
activity or necrosis to  suggest that this is an  atypical carcinoid, based on a small sample.

2.  Sections  show fragments  of  bronchial tissue,  widely  infiltrated by tumour nests with similar features to  those described for specimen 1.  The growth pattern is also partly trabecular. No necrosis is seen.  Up to two mitoses per  10 high power  fields  are identified.  Definite  evidence to
place the tumour in the atypical carcinoid category is not identified based on these small samples.

DIAGNOSIS
1&2 Left tracheal biopsy and right  main bronchus tumour biopsy - recurrent carcinoid tumour.

Loading...