The patient went on to have a resection.
Histology
Microscopic Description:
Sections show pieces of a high-grade glioma showing areas of necrosis, and vascular neogenesis. The tumor cells show astrocytic features with increased nuclear pleomorphism. A giant cell component is noted. Mitotic activity is increased. Bizarre mitotic figures are seen. Vascular neogenesis is seen. The tumor cells are strongly immunoreactive for GFAP.
Final Diagnosis: Glioblastoma with giant cell glioblastoma component.
Note: This case predates the recent (2016) revision WHO classification of CNS tumors and IDH status is not available. As such, this tumor would now be classified as a glioblastoma NOS.