Metastatic melanoma - kidney (pathology)

Discussion:

Tumors such as this, with no morphological clues to indicate the cell lineage, are often initially labeled as 'malignant spindled cell tumor'; examples of what a pathologist looks for include residual gland, mucin or keratin production (poorly differentiated carcinoma), melanin pigmentation (melanoma) or specific mesenchymal differentiation (e.g. rhabdomyoblasts, lipoblasts). When these morphological clues are not present, we attempt to uncover residual protein expression (immunohistochemistry), utilize cytogenetic profiling, or sometimes even resort to ultrastructural morphology (electron microscopy). In this case, the immunohistochemical tests confirmed metastatic melanoma.

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