Chondrosarcoma - sphenoid wing


The patient went on to have a resection. 


Sections show a moderately cellular cartilage-forming neoplasm with large areas of tumor necrosis. The tumor cells are round to polygonal with hyperchromatic nuclei and are embedded in a hyaline chondromatous matrix. There are foci, however, in which the tumor cells are stellate to spindle in shape, have slightly vacuolated cytoplasm and are embedded in a myxoid stroma. The tumor cells are diffusely and strongly positive for S-100 protein and negative for EMA and cytokeratin.

Final Diagnosis: chondrosarcoma (grade 2 of 3).